Related Experiment Video
Updated: May 22, 2025
07:04
Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
Published on: May 2, 2025
196
Immune checkpoint blockade for cancer therapy: current progress and perspectives.
Hongying Ye1,2, Weijie Liao1,2, Jiongli Pan1,2
1Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Journal of Zhejiang University. Science. B
|March 13, 2025
Summary
Immune checkpoint blockade (ICB) enhances anti-tumor immunity but faces challenges like limited response and side effects. This review explores ICB development, resistance strategies, and future directions for cancer immunotherapy.
Area of Science:
- Oncology
- Immunology
- Pharmacology
Background:
- Dysfunctional anti-tumor immune responses drive cancer progression.
- Immune checkpoint blockade (ICB) revitalizes T cell-mediated anti-tumor immunity.
- Approved ICB therapies target specific immune checkpoints on tumor and immune cells.
Purpose of the Study:
- To review the development and clinical applications of ICBs.
- To discuss strategies for overcoming resistance to ICB therapy.
- To explore future directions in ICB-based cancer immunotherapy.
Main Methods:
- Literature review of immune checkpoint inhibitors.
- Analysis of clinical trial data for ICB efficacy and safety.
- Synthesis of research on resistance mechanisms and novel therapeutic approaches.
Main Results:
- ICB is a powerful tool for cancer immunotherapy, normalizing host anti-tumor immunity.
- Identified immune checkpoints offer druggable targets for cancer treatment.
- Limited response rates and immune-related adverse events (irAEs) remain significant challenges.
Conclusions:
- ICB therapy has revolutionized cancer treatment by harnessing the immune system.
- Overcoming resistance and mitigating irAEs are critical for improving ICB outcomes.
- Future research should focus on novel ICB combinations and personalized treatment strategies.
More Related Videos
09:01Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
242
00:06An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
8.8K
Related Concept Videos
01:27Tumor Immunotherapy
457
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
457
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
01:30Cancer Vaccines
319
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
319
02:49Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
02:34Inhibition of Cdk Activity
4.6K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.6K
02:50Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K