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Peripheral chemoreceptors in respiratory oscillations.

S Lahiri, C Hsiao, R Zhang

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |June 1, 1985
    PubMed
    Summary

    Cardiorespiratory oscillations in cats were linked to carotid body chemoreceptor sensitivity. Dopamine receptor blockade increased oscillations, suggesting its role in damping these responses.

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    Area of Science:

    • Cardiovascular Physiology
    • Respiratory Physiology
    • Neuroscience

    Background:

    • Cardiorespiratory control instability can manifest as oscillations.
    • The role of carotid body chemoreceptors in these oscillations is not fully understood.

    Purpose of the Study:

    • To investigate the hypothesis that carotid body chemoreceptor sensitivity to blood gases influences cardiorespiratory control instability.
    • To explore the role of the dopaminergic system in the carotid body.

    Main Methods:

    • Studied anesthetized cats under various experimental conditions.
    • Administered domperidone (dopamine receptor blocker) and manipulated blood gases (PO2, CO2).
    • Performed bilateral section of carotid sinus nerves and induced hypotension.

    Main Results:

    • Domperidone administration increased carotid chemoreceptor activity and CO2 sensitivity, leading to oscillations in some cats.
    • Oscillations were observed during hypoxia and hypotension, and abolished by carotid sinus nerve section.
    • In some cats, oscillations occurred spontaneously, independent of blood gases or chemoreceptor activity.

    Conclusions:

    • The dopaminergic system in the carotid body appears to suppress chemoreceptor responses, damping cardiorespiratory oscillations.
    • The peripheral chemoreflex plays a critical role in the development of cardiorespiratory oscillations under specific conditions.

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