Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

299
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
299
Drug Delivery: Overview01:16

Drug Delivery: Overview

270
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
270
Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

2.7K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
2.7K
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

357
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
357
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

107
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
107
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

474
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
474

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fabrication of a hybrid cellularized cardiac patch <i>via</i> 3D bioprinting of alginate-gelatin-PEOz patterns on electrospun PLCL-PEOz nanofibers.

Journal of materials chemistry. B·2026
Same author

Continuous low-intensity ultrasound influences the transcriptomic profile in M1 macrophages by downregulating inflammation and promoting M2-like markers.

Scientific reports·2026
Same author

Hyaluronic acid-poly (vinyl alcohol) composite hydrogels with self-assembled peptide nanofibers as Bruch's membrane mimics for age-related macular degeneration treatment.

International journal of biological macromolecules·2026
Same author

Advances in 3D Bioprinting of Functional Skeletal Muscle Constructs: Focus on Preclinical Models and Evaluation Strategies.

ACS biomaterials science & engineering·2026
Same author

Synoviocyte-chondrocyte triculture model for early-stage PTOA: fibronectin fragment-induced catabolic effects <i>in vitro</i> and <i>in vivo</i>.

Frontiers in bioengineering and biotechnology·2025
Same author

Pharmacological and toxicological insights into the ayurvedic formulation Rasasindura.

Scientific reports·2025

Related Experiment Video

Updated: May 22, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:49

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

55

Drug Delivery Approaches for Rheumatoid Arthritis: Recent Advances and Clinical Translation Aspects.

Madhumithra Thangadurai1, Swaminathan Sethuraman2, Anuradha Subramanian2

  • 1SASTRA Deemed University.

Critical Reviews in Therapeutic Drug Carrier Systems
|March 14, 2025
PubMed
Summary

Rheumatoid arthritis (RA) treatment faces challenges due to limited drug efficacy and side effects. Novel smart drug delivery systems show promise for improved RA management and reduced joint damage.

More Related Videos

Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers
09:02

Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers

Published on: August 10, 2020

7.5K
A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model
11:03

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model

Published on: October 30, 2019

8.0K

Related Experiment Videos

Last Updated: May 22, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:49

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

55
Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers
09:02

Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers

Published on: August 10, 2020

7.5K
A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model
11:03

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model

Published on: October 30, 2019

8.0K

Area of Science:

  • Immunology
  • Rheumatology
  • Drug Delivery Systems

Background:

  • Rheumatoid arthritis (RA) is a complex autoimmune disease causing progressive joint deformity and systemic complications.
  • Current treatments offer palliative relief but have significant side effects and limited efficacy.
  • Existing drug delivery methods struggle to reach target sites effectively, exacerbating joint dysfunction.

Purpose of the Study:

  • To provide a comprehensive review of RA pathophysiology and disease progression.
  • To highlight the role of synoviocytes in joint damage and potential therapeutic targeting.
  • To discuss advanced smart drug delivery approaches for RA treatment.

Main Methods:

  • Literature review of RA pathophysiology, current treatments, and drug delivery strategies.
  • Analysis of synoviocyte contributions to RA pathogenesis.
  • Exploration of emerging smart drug delivery technologies for RA.

Main Results:

  • RA involves complex interactions, with synoviocytes like macrophages and fibroblast-like cells driving joint invasion and damage.
  • Current therapies are palliative and associated with multi-organ toxicity and infection risks.
  • Smart drug delivery systems offer potential for targeted therapy, enhanced efficacy, and reduced adverse effects.

Conclusions:

  • Targeting synoviocytes presents a promising therapeutic avenue for RA.
  • Smart drug delivery systems are crucial for overcoming current treatment limitations in RA.
  • Further research into novel strategies is essential to address unmet needs in RA management and prevent irreversible joint damage.