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Related Experiment Videos

Erythema multiforme associated with trazodone therapy: case report.

H E Ford, M A Jenike

    The Journal of Clinical Psychiatry
    |July 1, 1985
    PubMed
    Summary

    Trazodone use in a patient with treatment-resistant depression led to erythema multiforme (EM). Discontinuing trazodone resulted in symptom remission, suggesting a causal link between this antidepressant and EM.

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    Area of Science:

    • Dermatology
    • Psychiatry
    • Clinical Pharmacology

    Background:

    • Treatment-resistant depression poses a significant clinical challenge.
    • Antidepressant medications are a cornerstone of psychiatric treatment.
    • Erythema multiforme (EM) is an acute, immune-mediated mucocutaneous condition.

    Observation:

    • A 63-year-old woman with refractory depression was prescribed trazodone.
    • The patient subsequently presented with erythema multiforme (EM), characterized by lesions on limbs, hands, feet, palms, and soles.
    • The patient was also concurrently taking lithium, a mood stabilizer.

    Findings:

    • The clinical presentation and temporal association suggest trazodone as a potential trigger for erythema multiforme (EM).
    • Lithium, a medication the patient was also taking, has no established link to EM.
    • Discontinuation of trazodone led to the patient's remission from EM.

    Implications:

    • This case highlights the importance of considering trazodone as a potential cause of drug-induced erythema multiforme (EM).
    • Clinicians should be vigilant for EM development in patients initiating or continuing trazodone therapy.
    • Prompt discontinuation of the suspected agent is crucial for managing trazodone-induced EM.

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