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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Personality Disorders: Dependent and Obsessive-Compulsive01:24

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Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
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Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
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Sex Linked Disorders01:43

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.

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Related Experiment Video

Updated: May 19, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Genome-wide association study of obsessive-compulsive disorder.

S E Stewart1, D Yu, J M Scharf

  • 1Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Harvard Medical School, Boston, MA 02114, USA. sevelynstewart@gmail.com

Molecular Psychiatry
|August 15, 2012
PubMed
Summary

This study investigated the genetic underpinnings of obsessive-compulsive disorder (OCD) using a large international dataset. While no single gene reached genome-wide significance, top genetic signals showed enrichment for brain gene expression regulation, suggesting a role in OCD etiology.

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Area of Science:

  • Genetics
  • Neuropsychiatry
  • Molecular Biology

Background:

  • Obsessive-compulsive disorder (OCD) is a common and disabling neuropsychiatric condition with a complex genetic basis.
  • Identifying specific genetic variations contributing to OCD is crucial for understanding its etiology and developing targeted treatments.

Purpose of the Study:

  • To discover genetic variations predisposing individuals to obsessive-compulsive disorder (OCD).
  • To analyze genetic data from a large, multi-national cohort of OCD cases, their families, and controls.

Main Methods:

  • Genotyping of 1465 OCD cases, 5557 controls, and 400 trios using SNP microarrays.
  • Performing ancestry-stratified case-control and trio-based association analyses, followed by meta-analysis.
  • Examining top-ranked single nucleotide polymorphisms (SNPs) for enrichment of methylation QTLs and frontal lobe expression quantitative trait loci (eQTLs).

Main Results:

  • No SNPs reached genome-wide significance in the combined trio-case-control analysis.
  • The lowest P-values in case-control analysis were within DLGAP1.
  • A significant enrichment of methylation QTLs and frontal lobe eQTLs was observed among top-ranked SNPs.

Conclusions:

  • While no definitive OCD-associated SNPs were identified, the findings suggest that top genetic signals may influence gene expression in the brain.
  • These regulatory effects on brain gene expression could play a role in the development of obsessive-compulsive disorder (OCD).