Modelling orexinergic system in ageing in the African turquoise killifish

Area of Science:

• Neuroscience
• Gerontology
• Comparative Biology

Background:

• The orexinergic system, crucial for various physiological functions, is conserved across vertebrates.
• Its role in mammalian ageing and age-associated diseases is increasingly recognized.
• Research gaps exist in understanding orexinergic regulation during the ageing process.

Purpose of the Study:

• To review current findings on age-related orexinergic system regulation in mammals.
• To highlight the potential of Nothobranchius furzeri as a model organism for ageing research.
• To discuss the orexinergic system's involvement in healthy ageing and age-associated diseases.

Main Methods:

• Literature review of studies on the orexinergic system in mammals and Nothobranchius furzeri.
• Comparative analysis of ageing processes and orexinergic system function across species.
• Synthesis of current knowledge on neuroanatomical organization and functional roles.

Main Results:

• The orexinergic system shows age-related changes in mammals, influencing healthy ageing and diseases.
• Nothobranchius furzeri exhibits age-related neurodegeneration in its brain, mirroring human pathologies.
• This fish model provides a unique platform to investigate orexinergic mechanisms in ageing.

Conclusions:

• The orexinergic system is a key player in ageing and associated pathologies.
• Nothobranchius furzeri presents a valuable model for advancing our understanding of orexinergic regulation in ageing.
• Further research in this model can elucidate mechanisms relevant to human ageing and neurodegenerative diseases.