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Doppler Optical Coherence Tomography of Retinal Circulation
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Pupil wobble in point-scanning retinal optical coherence tomography systems.

Amit Narawane, Pablo Ortiz, Mark Draelos

    Optics Letters
    |March 14, 2025
    PubMed
    Summary

    This study introduces a novel pupil tracking Optical Coherence Tomography (OCT) method to correct for beam wander artifacts. The technique models and compensates for pupil wobble, enabling artifact-free volumetric imaging of samples like the human retina.

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    Area of Science:

    • Biomedical Optics
    • Ophthalmic Imaging
    • Optical Engineering

    Background:

    • Optical Coherence Tomography (OCT) systems generate high-resolution volumetric images using 2D scanning.
    • Sequential galvanometer scanners in OCT systems can cause pupil wobble, leading to signal loss and image artifacts.
    • Existing OCT methods struggle with artifacts caused by beam wander at the pupil plane.

    Purpose of the Study:

    • To develop and validate a method for analyzing and correcting pupil wobble in OCT systems.
    • To improve the quality of volumetric OCT images by eliminating signal loss and vignetting artifacts.
    • To enable artifact-free retinal imaging using advanced OCT techniques.

    Main Methods:

    • Deterministic analysis of pupil wobble patterns in OCT systems.
    • Implementation of pupil tracking OCT utilizing a 2D scanning mirror.
    • Placing the 2D scanning mirror anti-conjugate to the pupil plane for correction.
    • Theoretical and empirical modeling of pupil wobble phenomena.

    Main Results:

    • Successful modeling of pupil wobble patterns in OCT systems.
    • Demonstration of artifact correction through pupil tracking.
    • Acquisition of OCT images free from vignetting and signal loss artifacts.
    • Validation of the proposed method for diverse OCT system configurations.

    Conclusions:

    • Pupil tracking OCT effectively corrects for beam wander and associated artifacts.
    • The proposed method enhances the reliability and quality of OCT imaging, particularly in retinal applications.
    • This technique offers a robust solution for improving volumetric image acquisition in OCT systems.