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Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
Published on: October 6, 2022
Short Circuit: Understanding and Treating Neuropathic Pain
1New Jersey Spine Center, Chatham, NJ 07928, USA; Department of Physical Medicine & Rehabilitation, Rutgers-New Jersey Medical School, Newark, NJ 07103, USA.
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Toll-like receptors (TLRs) play a significant role in the development and maintenance of neuropathic pain and are expressed widely within the central nervous system on neurons, microglia, and astrocytes. TLRs detect both external (pathogen-associated molecular patterns) and internal (damage-associated molecular patterns) signals of inflammation. Chronic neuropathic pain has a prevalence of 6.9% and 10% of the general population. The diagnosis of neuropathic pain in the clinical setting commonly relies on a thorough history and physical examination. A multimodal and multidisciplinary approach is the gold standard of treatment, with medication management with pharmacotherapy as the primary treatment option.
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