Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Introduction to Functional Groups

Introduction to Functional Groups

Functional groups are group of atoms with specific chemical properties that occur within organic molecules and sometimes denoted as “R”. Functional groups are found along the carbon backbone of macromolecules can form chains or rings of carbon atoms. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of common functional groups
The table below summarizes some of the major functional groups in...

Overview of Advanced Functional Groups

Overview of Advanced Functional Groups

Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficient isolation and sensitive quantification of extracellular vesicles based on an integrated ExoID-Chip using photonic crystals.

Lab on a chip·2019

Same author

Bio-inspired photonic crystals for naked eye quantification of nucleic acids.

The Analyst·2019

Same author

Water Splitting-Assisted Electrocatalytic Oxidation of Glucose with a Metal-Organic Framework for Wearable Nonenzymatic Perspiration Sensing.

Analytical chemistry·2019

Same author

Molecular Mechanisms of AhpC in Resistance to Oxidative Stress in <i>Burkholderia thailandensis</i>.

Frontiers in microbiology·2019

Same author

Genomic landscape and its correlations with tumor mutational burden, PD-L1 expression, and immune cells infiltration in Chinese lung squamous cell carcinoma.

Journal of hematology & oncology·2019

Same author

Chronic hepatitis B virus infection is associated with a poorer prognosis in diffuse large B-cell lymphoma: a meta-analysis and systemic review.

Journal of Cancer·2019

Search research articles

Related Experiment Video

Updated: May 5, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

Progress in the application of functionalized covalent organic framework for bioanalysis.

Xuening Shi¹, Hang Li¹, Shuo Yao¹

¹State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, School of Public Health, Jilin University, Changchun, 130021, China.

Biosensors & Bioelectronics

|March 14, 2025

Summary

Functionalized covalent organic frameworks (COFs) enhance bioanalysis by combining COFs with nanomaterials. These hybrid materials offer improved detection of diverse biomolecules and microorganisms.

Keywords:

Bioanalysis Biosensing Covalent organic frameworks Functionalized strategy

More Related Videos

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Published on: July 14, 2015

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Published on: July 10, 2017

Related Experiment Videos

Last Updated: May 5, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Published on: July 14, 2015

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Published on: July 10, 2017

Area of Science:

Materials Science
Analytical Chemistry
Biotechnology

Background:

Covalent organic frameworks (COFs) are crystalline porous polymers with large surface areas and tunable pores, showing promise in analytical applications.
Bare COFs lack catalytic activity, limiting their use in complex bioanalysis.
Hybridization of COFs with nanomaterials can enhance their reactive activation and analytical performance.

Purpose of the Study:

To review the application of functionalized COFs in bioanalysis, covering nucleic acids, peptides, proteins, and microorganisms.
To discuss functionalization strategies, structural properties, and their role in different biosensing stages.
To compare the advantages of functionalized COFs with other hybrid materials in bioanalytical detection.

Main Methods:

Focus on functionalization strategies for COFs, including hybridization and modification with nanomaterials.
Analysis of unique structures and properties of functionalized COFs relevant to biosensing.
Review of diverse bioanalytical detection scenarios utilizing these hybrid materials.

Main Results:

Functionalized COFs demonstrate improved reactive activation and enhanced analytical performance for complex analytes.
These hybrid materials offer advantages in various stages of biosensing, from molecular recognition to signal transduction.
Specific examples of functionalized COFs applied to the detection of nucleic acids, peptides, proteins, and microorganisms are highlighted.

Conclusions:

Functionalized COFs represent a powerful platform for advanced bioanalysis, offering superior sensitivity and selectivity.
The strategic combination of COFs with nanomaterials unlocks new possibilities for sensitive and specific detection of biological targets.
Further research into functionalization strategies and material design will expand the utility of COFs in clinical diagnostics and biomedical research.