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Updated: Jul 16, 2026
In-vivo Centrifugation of Drosophila Embryos
Published on: June 23, 2010
From embryos to condensates: A developmental biologist's journey
1HHMI and Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, United States.
Abstract:
I am the Huntington Sheldon Professor of Medical Discovery in the Department of Molecular Biology and Genetics in the School of Medicine at the Johns Hopkins University, where I have been running a lab for 30 years. Our research focusses on the molecular control of embryonic polarity and germline development, with an emphasis on asymmetric cell division and biomolecular condensates. We have uncovered mechanisms that localize proteins and RNAs in the cytoplasm by controlling protein diffusion and RNA condensation. My lab has also characterized a repressive program that launches the germline by inhibiting somatic gene expression in germline progenitors.
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