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Therapeutic targeting of P2X receptors for orofacial pain

Jing Zhang1, Tianjuan Ju1, Yaru Qin1

  • 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Den-tistry, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.

Brain Research Bulletin
|March 14, 2025
PubMed

Insights

P2X receptors (P2XRs) are key in pain signaling. Antagonists targeting these receptors show promise for treating orofacial pain, with ongoing research and clinical trials yielding encouraging results.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Pain Research

Background:

  • P2X receptors (P2XRs) are ATP-gated ion channels crucial for nociception.
  • P2XRs directly facilitate pain signaling pathways.
  • Current research highlights P2XRs as significant therapeutic targets.

Purpose of the Study:

  • To review the structural and cellular aspects of P2XRs.
  • To elucidate P2XR mechanisms in orofacial pain.
  • To explore P2XR antagonists for orofacial pain management.

Main Methods:

  • Literature review of P2XR structure, localization, and function.
  • Analysis of molecular mechanisms and signaling pathways in orofacial pain.
  • Examination of P2XR antagonist development and clinical trial outcomes.

Main Results:

  • P2XRs are implicated in orofacial pain through specific molecular pathways.
  • Development of P2XR antagonists has shown efficacy in pain alleviation.
  • Clinical trials for P2XR antagonists have demonstrated positive outcomes.

Conclusions:

  • P2XRs represent a promising therapeutic target for orofacial pain.
  • Further development of P2XR antagonists is warranted for clinical application.
  • Targeting P2XRs offers a viable strategy for managing orofacial pain.
Keywords:
AntagonistClinical trialOrofacial painP2X receptorTherapeutic targeting

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