Related Experiment Video
Updated: May 22, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Enhancing solubility and dissolution of felodipine using self-nanoemulsifying drug systems through in vitro
Anil Pawar1, Shruti Dere1, Ramdas Pandhare1
1Mula Education Society's College of Pharmacy, Sonai, Tal-Newasa, Dist-Ahmednagar, Maharashtra, India.
Abstract:
The main objective of the present study was to improve the solubility and dissolution rate of felodipine (FLD), a drug that does not dissolve well in water, using a self-nanoemulsifying drug delivery system (SNEDDS). Many analyses have been performed in the laboratory using different oils, non-ionic surfactants, and water-soluble co-solvents to prepare FLD-loaded SNEDDS. It involves measurements of viscosity, refractive index, and droplet size. Solubility studies revealed the best way to load drugs, and pseudo-ternary phase diagrams showed the right amounts of surfactant and co-surfactant for preparing the nanoemulsion. An in vitro dissolution study showed that SNEDDS worked better than pure FLD, releasing over 95% of FLD within 20 min. SNEDDS loaded with felodipine are a good option for developing new oral medicines because they can hold more drugs, dissolve better, and dissolve more quickly. This new SNEDDS technology shows promise for improving the performance of drugs that do not dissolve well, which could lead to better therapeutic results.
More Related Videos
Related Concept Videos
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Factors Influencing Drug Absorption: Drug Dissolution
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
Theories of Dissolution: Diffusion Layer Model
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Factors Influencing Drug Absorption: Pharmaceutical Parameters

