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Disseminated HSV1 infection in a newborn - case report
Ceskoslovenska Patologie
|March 15, 2025
Summary
Neonatal Herpes simplex virus (HSV) infection, though rare, can be fatal. Autopsy revealed disseminated Herpes simplex virus 1 (HSV1) infection as the cause of an unexpected neonate death.
Area of Science:
- Neonatal medicine
- Infectious diseases
- Pathology
Background:
- Neonatal Herpes simplex virus (HSV) infections are uncommon but carry a high risk of mortality.
- Transmission typically occurs during birth but can also be postnatal.
- Disseminated HSV infection with multiorgan involvement is the most severe form.
Purpose of the Study:
- To report a case of unexpected neonatal death due to disseminated Herpes simplex virus 1 (HSV1) infection.
Main Methods:
- Case report detailing a neonate with unexplained demise.
- Autopsy examination to determine the cause of death.
- Histopathological and virological confirmation of Herpes simplex virus 1 (HSV1) infection.
Main Results:
- Autopsy revealed disseminated Herpes simplex virus 1 (HSV1) infection.
- The infection involved multiple organs, contributing to the fatal outcome.
Conclusions:
- Disseminated HSV1 infection can lead to unexpected and rapid mortality in neonates.
- This case underscores the importance of considering HSV1 in neonatal deaths, even without typical risk factors.
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