Effect of interferon tested in a model system for organogenesis

The effect of interferon (IFN) on growth and differentiation was examined in a model system for organogenesis--the embryonic murine kidney and its components. A relatively weak, transient inhibition of thymidine incorporation was recorded during the most active period of DNA synthesis in the presence of IFN at a concentration of 10(5) U/ml. No interference with cytodifferentiation or organogenesis could be shown by the end-point criteria used.