Multi-functional chitosan fiber-based dressings prepared by screen printing of baicalein and activated charcoal

In this study, chitosan needle-punched nonwovens (CS) was screen-printed with functional inks containing baicalein (Bai) and activated charcoal (AC) to prepare multifunctional dressings (AC + Bai@CS). The polyelectrolyte interaction between chitosan (matrix) and sodium carboxymethylcellulose (binder) facilitated the firm attachment of Bai and AC to the CS. Moreover, the screen-printed ink did not impact the surface hydrophilicity and the excellent air permeability (1837.5 ± 34.03 mm/s) of AC + Bai@CS. The printing of baicalein on the chitosan matrix resulted in a synergistic effect, leading to the AC + Bai@CS exhibiting enhanced antibacterial, antioxidant, and anti-inflammatory properties while maintaining cytocompatible characteristics. Furthermore, the deodorization rates of AC + Bai@CS against ammonia and acetic acid were 84.2 ± 1.6 % and 75.4 ± 1.1 %, respectively, indicating its potential deodorization effect on chronic wounds. This study presents a novel approach to developing multifunctional wound dressings via facile screen printing.