Related Experiment Video
Updated: May 22, 2025

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Novel Survivorship Paradigms in Head/Neck Cancer
Maria Armache1, Alexis Larson2, Rachel Stemme1
1Department of Otolaryngology, Johns Hopkins University, Baltimore, MD.
Head and neck cancer (HNC) survivorship care is complex, requiring coordinated support for side effects and quality of life. This review introduces the Nekhluydov Survivorship Care Framework to address HNC survivor needs comprehensively.
Area of Science:
- Oncology
- Cancer Survivorship Research
- Public Health
Background:
- Long-term care for head and neck cancer (HNC) survivors presents significant challenges.
- Survivors face diverse side effects impacting functionality and quality of life, despite improved survival rates.
- Evolving treatment paradigms, including de-escalation and targeted therapies, necessitate updated survivorship care models, especially for human papillomavirus (HPV)-related oropharyngeal cancers.
Purpose of the Study:
- To provide an overview of current HNC survivorship recommendations.
- To integrate novel evidence and understanding into a comprehensive survivorship care framework.
- To introduce the Nekhluydov Survivorship Care Framework for addressing HNC survivor needs.
Main Methods:
- Review of existing HNC survivorship recommendations.
- Incorporation of novel evidence and current understanding of survivorship care.
- Application of the Nekhluydov Survivorship Care Framework.
Main Results:
- Identification of a wide range of side effects and needs among HNC survivors.
- Highlighting the impact of these issues on functionality, quality of life, and survival.
- Presentation of the Nekhluydov Survivorship Care Framework as a novel approach to comprehensive care.
Conclusions:
- Coordinated and concerted survivorship care is essential for HNC survivors.
- The Nekhluydov Survivorship Care Framework offers a structured approach to HNC survivorship.
- Further research is needed for evidence-based, patient-centered, personalized HNC survivorship care and implementation strategies.
More Related Videos
11:28Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Related Concept Videos
Cancer Survival Analysis
Kaplan-Meier Approach
Cancer Stem Cells and Tumor Maintenance
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Assumptions of Survival Analysis