Recent Progress of Polymer-Based Biosensors for Cancer Diagnostic Applications: Natural versus Synthetic Polymers

Early diagnosis of cancer can significantly contribute to improving therapeutic outcomes and enhancing survival rates for cancer patients. Polymer-based biosensors have emerged as a promising tool for cancer detection due to their high sensitivity, selectivity, and low cost. These biosensors utilize functionalized polymers in different parts of the body to detect cancer biomarkers in biological samples. This approach offers several advantages over traditional detection methods, including real-time monitoring and noninvasive detection while maintaining high sensitivity and accuracy. This review discusses recent advances in the development of polymer-based biosensors for cancer detection including their design, fabrication, and performance. The essential characteristics of biosensing devices are presented, along with examples for natural and synthetic polymers commonly utilized in biosensors. Furthermore, strategies employed to tailor polymers to improve biosensing applications and future perspectives for the application of polymer-based biosensors in cancer diagnosis are also highlighted. Integrating these advancements will illuminate the potential of polymer-based biosensors as transformative tools in the early detection and management of cancer.