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Related Experiment Video

Updated: May 22, 2025

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

Beyond CCR7: dendritic cell migration in type 2 inflammation.

Audrey Meloun^1,2, Beatriz León¹

¹Innate Cells and Th2 Immunity Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

Frontiers in Immunology

|March 17, 2025

Summary

This summary is machine-generated.

Conventional dendritic cells (cDCs) migrate to lymph nodes for immune surveillance. Type 2 inflammation enhances this migration via pathways beyond CCR7, impacting T helper 2 cell differentiation.

Keywords:

7α,25-Dihydroxycholesterol (7α,25-OHC)CCR7 EBI2 (GPR183)cysteinyl leukotrienes (cysLTs)dendritic cell migration prostaglandins (PGs)sphingosine-1-phosphate (S1P)type 2 immune responses

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Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

Area of Science:

Immunology
Cell Biology
Molecular Biology

Background:

Conventional dendritic cells (cDCs) are key antigen-presenting cells vital for initiating and regulating T cell responses.
cDC migration from peripheral tissues to draining lymph nodes (dLNs) is crucial for immune surveillance and antigen presentation.
Chemokine receptor CCR7 typically mediates cDC migration to dLNs.

Purpose of the Study:

To investigate the mechanisms of cDC migration during type 2 immune responses.
To understand how cDC migration is regulated in diverse immune contexts.
To explore the role of non-CCR7 pathways in cDC trafficking during type 2 immunity.

Main Methods:

Review of existing literature on cDC migration and type 2 immunity.
Analysis of signaling pathways involved in cDC trafficking.
Exploration of lipid mediators' roles in cDC migration.

Main Results:

cDCs exhibit robust migration to dLNs during type 2 inflammation despite low CCR7 expression.
Type 2 immune responses utilize additional signaling pathways, including lipid mediators, to enhance cDC migration.
These pathways cooperate with CCR7 to promote cDC migration and T helper 2 (Th2) differentiation.

Conclusions:

Type 2 immune responses involve complex regulatory mechanisms controlling cDC migration.
Lipid mediators play a significant role in cDC trafficking during type 2 inflammation.
Understanding these mechanisms provides insights into differential control of cDC trafficking and immune responses.