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Updated: Jun 20, 2026

Chronic Imaging of Mouse Visual Cortex Using a Thinned-skull Preparation

Chronic Imaging of Mouse Visual Cortex Using a Thinned-skull Preparation

Published on: October 25, 2010

Multimodal Optical Imaging and Modulation through Smart Dura in Non-Human Primates.

Nari Hong^1,2, Sergio Montalvo Vargo³, Gaku Hatanaka^2,4

¹Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA.

Biorxiv : the Preprint Server for Biology

|March 17, 2025

Summary

This summary is machine-generated.

We developed Smart Dura, a large-scale neural interface for non-human primates (NHPs), enabling multimodal brain recordings and manipulations. This technology advances translational neurotechnology for human applications.

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Last Updated: Jun 20, 2026

Chronic Imaging of Mouse Visual Cortex Using a Thinned-skull Preparation

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Published on: October 25, 2010

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

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Area of Science:

Neuroscience
Biomedical Engineering
Translational Neurotechnology

Background:

Multimodal neural interfaces offer enhanced spatiotemporal resolution for recording and manipulating neuronal activity.
Current technologies are often limited to small animal models, hindering translation to larger brains like non-human primates (NHPs).

Purpose of the Study:

To demonstrate the multimodal applications of the newly developed large-scale neural interface, Smart Dura, in NHPs.
To showcase Smart Dura's capability in integrating various optical and electrophysiological techniques for comprehensive brain investigation.

Main Methods:

Developed Smart Dura, a large-scale neural interface for NHPs, providing electrophysiological recording and optical accessibility.
Combined Smart Dura with multiphoton microscopy (two-photon and three-photon), optical coherence tomography angiography (OCTA), and intrinsic signal optical imaging (ISOI).
Utilized Smart Dura for optical manipulations including photothrombotic lesioning and optogenetics.

Main Results:

Achieved fluorescence imaging up to 550 μm depth through the transparent Smart Dura.
Enabled simultaneous electrophysiology with OCTA and ISOI for assessing vascular and neural dynamics.
Demonstrated induction of ischemic stroke and optogenetic neuromodulation over a 20 mm diameter area.

Conclusions:

Smart Dura facilitates comprehensive investigations of brain dynamics in NHPs.
This multimodal interface significantly advances translational neurotechnology towards human applications.