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Related Experiment Video

Updated: May 22, 2025

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

A model for boundary-driven tissue morphogenesis.

Daniel S Alber^1,2, Shiheng Zhao^3,4,5, Alexandre O Jacinto⁶

¹Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08540.

|March 17, 2025

Summary

This summary is machine-generated.

Tissue deformations in fruit fly (Drosophila) embryos can be passive. Complex hindgut shape changes result from surrounding tissue movements, not internal forces, offering insights into developmental biology.

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Area of Science:

Developmental Biology
Biophysics
Morphogenesis

Background:

Tissue deformations during development are either active (internal) or passive (boundary-driven).
The Drosophila hindgut primordium serves as a model to study boundary-driven tissue morphogenesis.

Purpose of the Study:

To investigate the role of passive deformations in shaping the Drosophila hindgut.
To characterize the 3D deformations and kinematics of the hindgut primordium.

Main Methods:

Utilized the Drosophila hindgut primordium as a model system.
Constructed a minimal elastic ring model on an ellipsoidal surface to simulate deformations.
Quantified tissue kinematics using contour analysis.

Main Results:

Identified an intermediate triangular shape during hindgut 3D deformation.
Demonstrated that surrounding active tissue deformations passively shape the hindgut.
Showed hindgut deformation occurs in two stages: translation and symmetry breaking.
Validated the passive model against observed contour kinematics.

Conclusions:

Hindgut morphogenesis is a passive process driven by boundary forces and embryonic curvature.
Uniform boundary conditions can generate complex, non-uniform shape changes.
Provides a framework for understanding global morphology in developmental systems and blastopore-equivalent shapes across organisms.