Antifungal Susceptibility Testing - The Times They Are a Changin'

Area of Science:

• Medical Mycology
• Clinical Microbiology
• Pharmacology

Background:

• Antifungal susceptibility testing (AFST) is less established than antibacterial testing.
• A surge in antifungal drug development is imminent.
• This necessitates a reevaluation of AFST's role and capacity.

Purpose of the Study:

• To advocate for enhanced AFST capacity.
• To review emerging antifungal agents.
• To address challenges and interpretation issues in AFST.

Main Methods:

• Literature review of antifungal development.
• Analysis of AFST methodologies.
• Discussion of clinical implications and technical challenges.

Main Results:

• New antifungal agents are expected soon, increasing the need for AFST.
• Trailing growth in Candida species can complicate susceptibility interpretations.
• Standardization and management of AFST challenges are crucial.

Conclusions:

• Increased AFST capacity is essential to support new antifungal therapies.
• Understanding and managing AFST complexities, like trailing growth, is vital for accurate patient management.
• Proactive adaptation of AFST is required for the evolving antifungal landscape.