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Association Between Systemic Immunity-Inflammation Index (SII) and Fatigue, Cancer, and Cancer-Related Fatigue:
Li Sun1, Yanling Wu1, Lydia Idowu Akinyemi1
1School of Nursing and Rehabilitation, Nantong University, Nantong, Jiangsu, China.
Cancer Medicine
|March 17, 2025
Summary
The systemic immunity-inflammation index (SII) is linearly associated with fatigue, cancer, and cancer-related fatigue (CRF). Higher SII levels correlate with increased fatigue severity, especially in CRF patients.
Area of Science:
- Immunology
- Oncology
- Public Health
Background:
- The systemic immunity-inflammation index (SII) reflects systemic inflammation.
- Understanding SII's role in fatigue and cancer is crucial for patient management.
Purpose of the Study:
- To investigate the association between SII and fatigue, cancer, and cancer-related fatigue (CRF).
Main Methods:
- Retrospective cross-sectional study using NHANES data (2005-2018).
- SII calculated from platelet, neutrophil, and lymphocyte counts.
- Binary logistic regression and restricted cubic splines analyzed correlations and dose-response relationships.
Main Results:
- SII positively correlated with fatigue (1.43), cancer (1.67), and CRF (1.93) groups.
- A linear relationship was observed between SII and outcomes.
- Higher SII levels were linked to increased fatigue severity, with CRF showing a 171% increase in severe fatigue.
Conclusions:
- SII is a significant, linear predictor of fatigue, cancer, and CRF.
- Elevated SII is associated with heightened fatigue, particularly in the CRF population.
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