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Single-chain variable fragments in veterinary medicine: Intelligent design, efficient expression, and precision

Leilei Zhang1, Jiajia Jiang2, Wenjing Yang1

  • 1National Key Laboratory of Agricultural Microbiology，Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, Hubei 430070, China.

Biotechnology Advances
|July 27, 2026
PubMed
Summary

Single-chain variable fragment (scFv) antibodies offer veterinary advancements but face challenges. This review explores AI design, expression systems, and applications to guide the development of next-generation veterinary biologics.

Keywords:
Artificial intelligence (AI) designExpression systemsPrecision medicineSingle-chain variable fragmentsVeterinary biologics

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