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Polypharmacology: new drugs in 2023-2024
Piotr Ryszkiewicz1, Barbara Malinowska2, Eberhard Schlicker3
1Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, Białystok, 15-222, Poland. piotr.ryszkiewicz@umb.edu.pl.
Pharmacological Reports : PR
|March 17, 2025
Summary
Multi-target-directed ligands (MTDLs) offer a promising approach to treating complex diseases. A recent analysis of drugs approved in Germany (2023-2024) shows polypharmacology remains a prevalent strategy.
Area of Science:
- Pharmacology
- Drug Design
- Medicinal Chemistry
Background:
- Chronic diseases involve complex, interconnected pathways, challenging traditional single-target treatments.
- Single-target therapies often lead to limited effectiveness, resistance, or relapse.
- Polypharmacology, using multi-target-directed ligands (MTDLs), addresses biological complexity.
Purpose of the Study:
- To evaluate the prevalence of the polypharmacology approach in newly approved drugs.
- To analyze drugs approved in Germany between 2023 and 2024 for adherence to the MTDL concept.
Main Methods:
- Analysis of drug approval data in Germany for the years 2023-2024.
- Identification of drugs designed using the polypharmacology concept (MTDLs).
Main Results:
- Out of 73 newly approved substances, 18 align with the polypharmacology concept.
- These include 10 antitumor agents, 5 for autoimmune disorders, 1 for hand eczema, 1 antidiabetic/anti-obesity drug, and 1 modified corticosteroid.
Conclusions:
- The polypharmacology approach, utilizing MTDLs, continues to be a significant trend in drug development.
- MTDLs demonstrate potential for treating complex multifactorial conditions, offering advantages over traditional therapies.
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