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Patient-Self Inflicted Lung Injury (P-SILI): An Insight into the Pathophysiology of Lung Injury and Management
Himanshu Deshwal1, Ahmed Elkhapery2, Rudra Ramanathan3
1Division of Pulmonary, Sleep and Critical Care Medicine, Department of Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Journal of Clinical Medicine
|March 17, 2025
Summary
Patient self-inflicted lung injury (P-SILI) can worsen acute respiratory distress syndrome (ARDS) by increasing lung injury through spontaneous breathing efforts. Further research is needed to understand P-SILI
Area of Science:
- Critical Care Medicine
- Pulmonology
- Respiratory Physiology
Background:
- Acute respiratory distress syndrome (ARDS) presents significant morbidity and mortality.
- Emerging research highlights the role of spontaneous breathing effort in exacerbating lung injury.
Purpose of the Study:
- To review the physiological mechanisms of patient self-inflicted lung injury (P-SILI).
- To discuss novel detection methods for P-SILI.
- To summarize current respiratory management strategies for ARDS patients with P-SILI.
Main Methods:
- Literature review of animal and human studies on P-SILI.
- Analysis of pathophysiological mechanisms linking spontaneous breathing to lung injury.
- Synthesis of data on diagnostic tools and therapeutic interventions.
Main Results:
- Excessive spontaneous breathing effort can perpetuate lung injury in ARDS.
- P-SILI is a critical phenomenon requiring further clinical investigation.
- Various tools and methods are being developed to detect P-SILI.
Conclusions:
- Understanding P-SILI is crucial for optimizing ARDS management.
- Further clinical trials are necessary to validate the impact of P-SILI on ARDS outcomes.
- Tailored respiratory support strategies may mitigate P-SILI.
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