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Updated: May 21, 2025

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
Published on: January 26, 2019
Recovery of Antibody Immunity After a Resurgence of Respiratory Syncytial Virus Infections
Frederic Reicherz1,2,3, Marina Viñeta Paramo1,4, Jeffrey N Bone1
1British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Abstract:
Longitudinal measurements of respiratory syncytial virus (RSV) immunity over 4 winter seasons reveal that viral neutralization titers, RSV prefusion F protein (pre-F)-specific immunoglobulin M and immunoglobulin G (IgG) levels, and RSV antibody-dependent cellular phagocytosis function gradually returned to prepandemic levels in female healthcare and school workers of childbearing age after 2 winter seasons, following the resurgence of RSV cases in the Vancouver metropolitan region (British Columbia, Canada). In contrast, pre-F IgG avidity profiles remained unchanged. These findings support the notion that repeated viral infections are necessary to maintain high RSV antibody levels in the population.
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