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Updated: May 21, 2025

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
IL-33 and ILC2 in pancreatic cancer: good, bad or a bit of both?
Charlotte Simpson1, Thomas Yip1, Timotheus Y F Halim1
1University of Cambridge, CRUK Cambridge Institute, Cambridge, CB2 0RE, UK.
Abstract:
Tertiary lymphoid structures (TLS) are associated with anticancer immunity, but the mechanisms underpinning their formation remain poorly understood. Amisaki et al. have recently shown that IL-33 mediates ILC2 gut-tumoral migration and promotes TLS formation in pancreatic ductal adenocarcinoma (PDAC) by inducing group 2 innate lymphoid cell (ILC2) Ltb expression. This study highlights new potential therapeutic avenues to enhance immunotherapy.
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