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Related Experiment Video

Updated: May 21, 2025

Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI
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Racial Differences in Liver Fibrosis Burden.

Michael L Attanasi1, Mathew J Gregoski2,3, Don C Rockey4,5,6

  • 1Department of Internal Medicine, North Shore University Hospital, Manhasset, NY, USA.

Digestive Diseases and Sciences
|March 19, 2025
PubMed
Summary

Racial disparities exist in liver fibrosis. White patients showed a higher prevalence of advanced fibrosis (cirrhosis) compared to Black patients, irrespective of the underlying liver disease cause. This suggests potentially greater fibrosis risk or progression in White individuals.

Keywords:
BiopsyCirrhosisEthnicityHistologyPathologyRaceSteatosis

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Area of Science:

  • Hepatology
  • Fibrosis Research
  • Racial Health Disparities

Background:

  • Liver histology is the standard for staging liver fibrosis, a key predictor of patient outcomes.
  • Previous research suggests potential variations in fibrosis development susceptibility across different racial groups.

Purpose of the Study:

  • To investigate if susceptibility to developing liver fibrosis differs among racial groups.
  • To analyze liver biopsy data to compare fibrosis severity and etiological factors between racial cohorts.

Main Methods:

  • Retrospective analysis of liver biopsy histology from patients over 18 years old (1/1/2013-7/1/2021).
  • Exclusion of patients with malignancy, liver metastases, or incomplete data.
  • Fibrosis staged using the Batts-Ludwig system (F0-F4).
  • Propensity matching of racial groups based on age, gender, diabetes, alcohol consumption, and social vulnerability index.

Main Results:

  • 1101 patients with fibrosis scores were analyzed; 23% were Black.
  • After matching, Black patients had higher rates of Hepatitis C and autoimmune hepatitis.
  • White patients showed higher rates of metabolic dysfunction-associated steatotic liver disease.
  • White patients had a significantly higher likelihood of cirrhosis (F4) than Black patients (39% vs. 30%, p<0.05).

Conclusions:

  • White patients exhibited a greater burden of advanced fibrosis (cirrhosis) compared to Black patients, independent of liver disease etiology.
  • Findings indicate that fibrosis risk and/or progression may be more severe in White individuals than in Black individuals.