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Enhancement of small intestine function by gastrin
The Journal of Surgical Research
|June 1, 1985
Summary
Gastrin significantly enhances small intestine (SI) development and nutrient absorption in a rat model. This study demonstrates gastrin
Area of Science:
- Gastroenterology
- Developmental Biology
- Endocrinology
Background:
- Infants with small intestine (SI) abnormalities often suffer from malabsorption.
- Gastrin is a potential trophic hormone for SI epithelial cells.
Purpose of the Study:
- To evaluate the effect of gastrin on the function and maturation of developing SI.
- To assess gastrin's impact on nutrient absorption in a rat fetal intestine transplant model.
Main Methods:
- Utilized a rat fetal intestine transplant model with jejunoileal segments.
- Administered gastrin-17 or saline via continuous infusion for 14 days.
- Assessed intestinal maturation via DNA concentration, disaccharidase activity, and nutrient absorption.
Main Results:
- Gastrin significantly increased mucosal DNA concentration (cell mass) (P < 0.01).
- Gastrin administration led to a significant increase in galactose absorption (P < 0.01).
- Gastrin also significantly enhanced glycine absorption (P < 0.05).
Conclusions:
- Exogenous gastrin administration promotes SI maturation and enhances carbohydrate and protein absorption.
- Gastrin shows potential as a therapeutic agent for malabsorptive conditions.
- This study provides the first evidence of exogenous gastrin improving nutrient absorption in a developing SI model.