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FDG PET/CT Images Demonstrating Subclinical Pancreatitis in a Patient on a GLP-1 Receptor Agonist
Robert Lenkov1, Tyler Berman2, Inderjit Mehmi3
1Department of Biological Sciences, University of California-San Diego, La Jolla, CA.
None:
An 83-year-old man with basal cell carcinoma was referred for an 18 F-FDG PET/CT scan for staging. The FDG PET/CT scan revealed diffuse increased radiotracer uptake within the pancreas without CT abnormality, which raised concern for pancreatitis. Although this man was clinically asymptomatic, a lipase level obtained after the PET/CT scan was elevated, confirming the diagnosis. This man was noted to be on tirzepatide, which is a GLP-1 receptor agonist medication used for type 2 diabetes and weight loss. No other causes of pancreatitis were identified in this man, and therefore, the cause was attributed to this medication.
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Assessment:
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Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...