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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

320
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

268
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
268

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Updated: May 21, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Donor and Recipient Polygenic Risk Scores Influence Kidney Transplant Function.

Kane E Collins1,2,3, Edmund Gilbert1,2, Vincent Mauduit4

  • 1School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

Transplant International : Official Journal of the European Society for Organ Transplantation
|March 19, 2025
PubMed
Summary
This summary is machine-generated.

Donor and recipient genetic risk scores for kidney function traits show a small, statistically significant association with kidney transplant graft function early after transplantation. However, this genetic influence is currently too small to have clinical applications in predicting transplant success.

Keywords:
eGFRgraft functiongraft survivalmultivariable modelspolygenic risk scores

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Area of Science:

  • Nephrology
  • Genetics
  • Transplantation Immunology

Background:

  • Kidney transplant outcomes are influenced by various factors, but significant unexplained variability persists.
  • Donor and recipient genetic predispositions may contribute to this variability in graft function.

Purpose of the Study:

  • To investigate the association between polygenic risk scores (PRSs) for kidney function-related traits in donors and recipients and kidney transplant outcomes.
  • To determine if PRSs explain any of the unexplained variability in graft function post-transplantation.

Main Methods:

  • Assembled a cohort of 6,060 living and deceased kidney donor-recipient pairs.
  • Calculated PRSs for kidney function-related traits in both donors and recipients.
  • Assessed the association of PRSs with recipient estimated glomerular filtration rate (eGFR) at 1- and 5-year post-transplant and graft failure.

Main Results:

  • Donor hypertension PRS, eGFR PRS, and intracranial aneurysm PRS, along with recipient eGFR PRS, were associated with 1-year post-transplant eGFR.
  • PRSs cumulatively explained an additional 1% of variation in eGFR at both 1- and 5-year post-transplant, beyond clinical factors.
  • No significant association was found between PRSs and long-term graft survival.

Conclusions:

  • Donor and recipient PRSs demonstrate a small but statistically significant association with early graft function (1- and 5-year post-transplant eGFR).
  • The current predictive power of PRSs for kidney transplant outcomes is limited and unlikely to have immediate clinical utility.
  • Further research is needed to enhance PRS performance for potential clinical application in transplantation.