Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormonal Regulation01:33

Hormonal Regulation

32.8K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.8K
Assessment of the Cardiovascular System I: Subjective Data01:23

Assessment of the Cardiovascular System I: Subjective Data

254
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
254
Kidney Structure01:45

Kidney Structure

68.3K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
68.3K
Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

1.2K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
1.2K
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

641
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
641
Nephrons01:10

Nephrons

1.9K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obesity, Severe Obesity, and Abdominal Obesity in US Youth and Adults From 1999 to 2023.

Circulation·2026
Same author

Cognitive Function and Cardiac Rehabilitation Attendance in Older Adults With Cardiovascular Disease Events: ATHEROSCLEROSIS RISK IN COMMUNITIES STUDY.

Journal of cardiopulmonary rehabilitation and prevention·2026
Same author

Gaps, Barriers, and Facilitators to Implementing Comprehensive Medication Management in Cardiovascular-Kidney-Metabolic Care: A Qualitative Study.

Journal of the American College of Clinical Pharmacy : JACCP·2026
Same author

Proteomic Signatures of 3-Year Progression From Impaired Fasting Glucose to Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study.

Diabetes care·2026
Same author

A Framework for Risk-Based Implementation of Combination Therapy in CKD: Who, Why, When, and How?

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Systematic examination of the PREVENT equations for cardiovascular disease risk.

American journal of preventive cardiology·2026

Related Experiment Video

Updated: May 21, 2025

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

20.3K

Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Case-Based Narrative Review.

Aamir Javaid1, Essa Hariri1, Bige Ozkan1

  • 1Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md.

American Journal of Medicine Open
|March 19, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces the American Heart Association cardiovascular-kidney-metabolic (CKM) health construct using 4 hypothetical cases. It demonstrates applying the CKM staging system and PREVENT risk calculator for personalized patient management.

Keywords:
CardiologyNephrologyPrevention

More Related Videos

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.2K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

768

Related Experiment Videos

Last Updated: May 21, 2025

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

20.3K
Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.2K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

768

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Health

Background:

  • The American Heart Association developed the cardiovascular-kidney-metabolic (CKM) health construct.
  • Integrating CKM into clinical practice requires practical application examples.

Purpose of the Study:

  • To illustrate the application of the CKM health construct in diverse clinical scenarios.
  • To demonstrate the use of the CKM staging system and PREVENT risk calculator.
  • To explore clinical management strategies tailored to CKM stages and individual risk profiles.

Main Methods:

  • Presentation of 4 distinct hypothetical patient cases.
  • Application of the CKM staging system to each case.
  • Utilization of the PREVENT risk calculator for risk assessment.
  • Discussion of clinical management considerations based on CKM stages and risk.

Main Results:

  • Case 1: Management of stage 1 obesity and impaired glucose tolerance within the CKM framework.
  • Case 2: Addressing metabolic risk factors and moderate-risk chronic kidney disease (CKD).
  • Case 3: Navigating subclinical atherosclerotic cardiovascular disease with comorbidities.
  • Case 4: Comprehensive management of complex conditions including prior myocardial infarction, heart failure, atrial fibrillation, and CKD.

Conclusions:

  • The CKM construct provides a novel framework for assessing and managing cardiovascular, kidney, and metabolic health.
  • Integrating risk calculators and staging systems enhances personalized patient care.
  • These cases highlight the adaptability of the CKM approach across a spectrum of clinical presentations.