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[Factors associated with prognosis and treatment failure in children with acute lymphoblastic leukemia]

Meng-Meng Yin1, Qun Hu1, Ai-Guo Liu1

  • 1Department of Pediatric Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|March 19, 2025
PubMed

Insights

Relapse is the main cause of treatment failure in childhood acute lymphoblastic leukemia (ALL). Identifying risk factors like high white blood cell count and severe adverse events can improve long-term survival.

Area of Science:

  • Pediatric Hematology
  • Oncology
  • Clinical Research

Context:

  • Acute lymphoblastic leukemia (ALL) is a significant challenge in pediatric oncology.
  • Understanding treatment failure and prognosis is crucial for improving outcomes.

Purpose:

  • To identify factors influencing prognosis and treatment failure in pediatric ALL.
  • To analyze the impact of various clinical and biological markers on patient outcomes.

Summary:

  • A retrospective study of 341 children with ALL identified initial WBC count ≥50×109/L, positive minimal residual disease, and severe adverse events as independent risk factors for treatment failure.
  • Relapse was the primary cause of treatment failure (80% of cases), with bone marrow relapse being most common.
  • High-risk status, T-cell ALL, relapse, and severe adverse events were independent risk factors for long-term survival.

Impact:

  • Findings highlight relapse as the main driver of treatment failure in pediatric ALL.
  • Identifying key risk factors can guide targeted interventions to improve survival rates.
  • Preventing relapse is critical for enhancing the long-term prognosis of children with ALL.
Abstract

Keywords:
Acute lymphoblastic leukemiaChildPrognosisRisk factorTreatment failure

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