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Large-scale Zebrafish Embryonic Heart Dissection for Transcriptional Analysis
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Correction to: Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor

Julia Nöth1, Paul Michaelis2, Lennart Schüler3

  • 1Department of Ecotoxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraβe 15, 04318, Leipzig, Germany. julia.noeth@ufz.de.

Archives of Toxicology
|March 19, 2025
PubMed
Summary

No abstract available in PubMed .

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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