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Updated: May 21, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
Chemical Constituents with Ferroptosis Inhibitory Activity of the Deep-Sea-Derived Penicillium paxilli
Zhe-Wen Chen1, Yuan Wang2, Rong Chao2
1Shenzhen Clinical College of Integrated Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, China.
Abstract:
A rare tri-nor-non-paspaline indole diterpenoid (penpaxin A, 1), a new 1,3-dioxolane derivative (penpaxin B, 9), and 19 known compounds (2-8 and 10-21) were isolated from the deep-sea-derived Penicillium paxilli MCCC 3A01133. The structures of the new compounds were established by detailed analyses of the NMR, HRESIMS, and ORD data. 3-Deoxo-4b-deoxypaxilline (5) and paspaline (7) exhibited potent inhibition on RSL3-induced ferroptosis with the EC50 values of 2.88 and 0.21 µM, respectively.
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