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Related Experiment Video

Updated: May 21, 2025

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Published on: July 14, 2023

Vibrational exercise for Crohn's to observe response (VECTOR): Protocol for a randomized controlled trial.

Jonathan Sinclair¹, Johanne Brooks-Warburton^2,3, Lauren Baker²

¹Research Centre for Applied Sport, Physical Activity and Performance, School of Sport and Health Sciences, Faculty of Allied Health and Wellbeing, University of Central Lancashire, Preston, Lancashire, United Kingdom.

|March 19, 2025

Summary

Whole body vibration (WBV) may offer a new non-drug approach for Crohn's disease (CD). This study will test if WBV improves quality of life and reduces symptoms in CD patients.

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Last Updated: May 21, 2025

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Area of Science:

Gastroenterology and Immunology
Rehabilitation Medicine
Clinical Trial Methodology

Background:

Crohn's disease (CD) is a chronic inflammatory disorder impacting physical and mental health.
Current pharmaceutical treatments for CD have limitations including side effects and low adherence.
Whole body vibration (WBV) is a non-invasive technique with potential to address CD symptoms.

Purpose of the Study:

To investigate the impact of WBV as a non-pharmaceutical intervention for Crohn's disease.
To evaluate the effectiveness of WBV combined with lifestyle education compared to lifestyle education alone.

Main Methods:

A 6-week, parallel randomized controlled trial involving 168 participants with CD.
Participants will be assigned to either WBV plus lifestyle education or lifestyle education only.
Health-related quality of life, fatigue, anxiety, pain, physical fitness, and biological markers will be assessed.

Main Results:

The primary outcome is the change in health-related quality of life from baseline to post-intervention.
Secondary outcomes include changes in fatigue, anxiety, pain, fitness, and inflammatory markers.
Statistical analysis will use an intention-to-treat approach with linear mixed-effects models.

Conclusions:

WBV presents a promising non-invasive therapeutic option for managing Crohn's disease.
This trial will provide crucial data on the efficacy of WBV in improving patient outcomes.
Findings may support the integration of WBV into standard care for CD management.