Related Experiment Video
Updated: May 21, 2025

In vivo Evaluation of Mucociliary Clearance in Mice
Published on: December 18, 2020
Interplay between respiratory viruses and cilia in the airways
Katie Horton1,2,3, Peter A C Wing4,5,3, Claire L Jackson1,2,3
1School of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK.
Abstract:
The airway epithelium is the first point of contact for inhaled pathogens. The role of epithelial cells in clearance, infection and colonisation of bacteria is established. The interactions of respiratory viruses and cilia is less understood, but viruses are known to target ciliated epithelial cells for entry, replication and dissemination. Furthermore, some respiratory viruses impair and/or enhance ciliary activity. This review examines what is known about the interactions between cilia and viral infection and how respiratory viruses effect cilia function with subsequent consequences for human health. We discuss the models which can be used to investigate the relationship between respiratory viruses and the host airway.
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