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Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology

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Portable and rapid solid sample preparation system utilizing twin-screw mechanism for diagnostic applications.

Ji Hyo Park^1,2, Yeong-Eun Yoo^1,3, Jae-Ho Jin⁴

¹Nano Lithography and Manufacturing Research Center, Korea Institute of Machinery and Materials, 156 Gajeongbuk-ro, Daejeon, 34103, South Korea. kkim@kimm.re.kr.

|March 20, 2025

Summary

A new twin-screw mechanical maceration system rapidly processes solid samples for diagnostics. This compact, efficient device significantly reduces preparation time for various sample types, improving accessibility for biomedical applications.

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Area of Science:

Biomedical Engineering
Analytical Chemistry
In Vitro Diagnostics

Background:

Solid specimen processing is vital for diagnostics but often hindered by time-consuming methods and large equipment.
Current techniques limit the integration of solid samples into rapid diagnostic workflows.

Purpose of the Study:

To develop a novel, rapid, and portable system for efficient solid sample preparation.
To overcome limitations of conventional methods in processing diverse solid samples for analytical testing.

Main Methods:

Introduction of a twin-screw mechanical maceration system utilizing counter-rotating screws for high shear force generation.
Validation of the system's efficiency in bacterial elution from plant tissues and single-cell dissociation from animal tissues.
Exploration of scalability and portability using a 3D-printed miniaturized device.

Main Results:

Achieved bacterial elution from plant samples in under 1 minute, 30x faster than conventional stomaching.
Generated single-cell suspensions from animal tissues within 1 minute, accommodating various sample sizes.
Demonstrated comparable performance with a miniaturized, 3D-printed device enabling manual, power-free operation.

Conclusions:

The twin-screw system offers a rapid, compact, and adaptable solution for solid sample preparation.
This innovation significantly outperforms traditional methods, with broad potential in point-of-care diagnostics, tissue analysis, and monitoring applications.