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Global trends and hotspots in macrophage research related to hypertension from 2015-2024: bibliometric research and

Xuefei Wang1, Yemao Chai1, Ye Dou1

  • 1Beijing University of Chinese Medicine, Beijing, China.

Frontiers in Immunology
|March 20, 2025
PubMed

Insights

Research on hypertension and macrophages shows increasing publications. Macrophages are key in hypertension development and may offer treatment targets, but more research is needed on their mechanisms.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Bibliometrics

Background:

  • Hypertension is a global health burden, often linked to chronic inflammation.
  • Macrophages play a critical role in the development and progression of hypertension.
  • Understanding the macrophage-hypertension link is essential due to increasing research.

Purpose of the Study:

  • To analyze research trends and identify key areas in macrophage-related hypertension studies over the last decade (2015-2024).
  • To visualize the current state of research, including regulatory mechanisms, related diseases, and lifestyle factors.
  • To highlight inflammation as a central research hotspot.

Main Methods:

  • Bibliometric analysis of 2,013 articles and reviews published between 2015 and 2024 from Web of Science Core Collection.
  • Utilized VOSviewer, CiteSpace, and Scimago Graphica for data analysis and visualization.
  • Focused on co-cited references to identify research clusters and trends.

Main Results:

  • A significant annual increase in publications concerning hypertension and macrophages.
  • Inflammation identified as the primary research hotspot and keyword cluster.
  • PLOS ONE and Li, Hui-Hua identified as the leading journal and prolific author, respectively.

Conclusions:

  • Bibliometric analysis summarizes key findings in macrophage-hypertension research over the past 10 years.
  • Macrophages represent potential therapeutic targets for hypertension.
  • Further investigation is required to elucidate the specific pathophysiological mechanisms involved.
Abstract

Keywords:
bibliometrichotspotshypertensionmacrophagevisualization

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