Assessment of genetically modified maize DAS1131 (application GMFF-2021-1530).

Area of Science:

• Agricultural Biotechnology
• Genetics and Molecular Biology
• Food Safety Science

Background:

• Genetically modified maize DAS1131 was developed using genetic engineering to provide resistance to lepidopteran pests and tolerance to glyphosate herbicide.
• The genetic modification involved the introduction of the cry1Da2 and dgt-28 epsps expression cassettes.

Purpose of the Study:

• To assess the food and feed safety of genetically modified maize DAS1131.
• To evaluate potential risks to human and animal health and the environment associated with maize DAS1131.
• To compare the safety and nutritional profile of maize DAS1131 with its conventional counterpart and other non-GM varieties.

Main Methods:

• Molecular characterization and bioinformatic analyses were performed.
• Agronomic, phenotypic, and compositional characteristics were compared between maize DAS1131 and conventional maize.
• Toxicity and allergenicity assessments of introduced proteins (Cry1Da2 and DGT-28 EPSPS) were conducted.
• Environmental safety was evaluated concerning the release of maize DAS1131 into the environment.

Main Results:

• Molecular and bioinformatic analyses did not reveal issues requiring food/feed safety assessment.
• No significant safety or nutritional concerns were identified, except for a minor difference in crude fat content.
• The introduced Cry1Da2 and DGT-28 EPSPS proteins were found not to be toxic or allergenic.
• Maize DAS1131 demonstrated no adverse effects on human/animal health or the environment compared to conventional varieties.

Conclusions:

• Genetically modified maize DAS1131 is as safe as its conventional counterpart and tested non-GM varieties for food, feed, and environmental use.
• No post-market monitoring for food/feed is deemed necessary.
• Environmental release of maize DAS1131, including viable grains, does not raise environmental safety concerns.