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Updated: May 21, 2025

Measuring the Subjective Value of Risky and Ambiguous Options using Experimental Economics and Functional MRI Methods
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Published on: September 19, 2012

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The regulatory role of ZFAS1/miRNAs/mRNAs axis in cancer: a systematic review

Rahul Kumar Singh1, Surojit Mandal1, Adrija Mohanta1

  • 1Non-Coding RNA and Cancer Biology Laboratory, Department of Zoology, Central University of Punjab, Ghudda, Bathinda, 151401, India.

Oncology Research
|March 20, 2025
PubMed
Abstract

Insights

Zinc Finger Antisense 1 (ZFAS1) acts as a sponge for miRNAs, impacting cancer development. Targeting the ZFAS1-miRNA-mRNA axis offers potential for novel cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Zinc Finger Antisense 1 (ZFAS1) is implicated in cancer development.
  • The precise interactions between ZFAS1, microRNAs (miRNAs), and messenger RNAs (mRNAs) in cancer are not fully elucidated.

Purpose of the Study:

  • To review and analyze the existing literature on the ZFAS1/miRNA/mRNA axis in cancer.
  • To investigate the regulatory roles and potential therapeutic implications of this axis.

Main Methods:

  • Systematic literature review following PRISMA guidelines across PubMed, Google Scholar, and ScienceDirect.
  • Bioinformatic analysis to identify ZFAS1-miRNA interactions and assess patient survival data.
  • Analysis of signaling pathways and molecular functions associated with the ZFAS1 axis.

Main Results:

  • ZFAS1 functions as a miRNA sponge, with significant correlation observed for miR-150-5p.
  • Elevated ZFAS1 expression is linked to poor prognosis in ovarian, sarcoma, and pancreatic cancers.
  • The ZFAS1/miRNA/mRNA axis involves key pathways like STAT3, SKA1, LPAR1, and Wnt signaling, and impacts RNA binding and ribonucleoprotein formation.

Conclusions:

  • The ZFAS1-miRNA-mRNA axis plays a crucial role in cancer progression.
  • Understanding this axis provides insights into potential therapeutic targets for effective cancer management.
  • This review highlights the collective role of ZFAS1, miRNAs, and mRNAs in cancer development.
Keywords:
Cancer biomarkerLncRNAZinc finger antisense 1 (ZFAS1)mRNAsmiRNA

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