Related Experiment Video
Updated: May 21, 2025
08:05
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
40.0K
Sex differences in asthma: omics evidence and future directions
Bichen Peng1, Weiyi Ye1, Shuai Liu2
1College of Medical Information and Artificial Intelligence, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Frontiers in Genetics
|March 20, 2025
Summary
Sex differences in asthma genetics are not fully understood. This review explores omics findings to advance personalized asthma treatment strategies for all patients.
Area of Science:
- Genetics and genomics
- Respiratory medicine
- Precision medicine
Background:
- Asthma is a complex, heterogeneous respiratory disease with varying prevalence and severity across age and sex.
- High-throughput "omics" technologies offer new avenues for investigating the genetic underpinnings of asthma.
- Current understanding and clinical guidelines lack comprehensive sex-specific insights into asthma's genetic mechanisms.
Purpose of the Study:
- To review recent "omics" findings regarding sex differences in asthma.
- To discuss the integration of multidimensional omics data for deeper insights.
- To advance precision and effectiveness in sex-specific asthma management.
Main Methods:
- Literature review of omics-level studies focusing on sex differences in asthma.
- Analysis of genetic, epigenetic, and transcriptomic data related to asthma.
- Synthesis of findings to identify sex-specific patterns and mechanisms.
Main Results:
- Omics data reveal significant sex-specific variations in asthma's genetic architecture.
- These differences impact disease susceptibility, progression, and potentially treatment response.
- Current evidence highlights the need for sex-stratified analysis in asthma research.
Conclusions:
- Further exploration of sex differences in asthma genetics is crucial.
- Integrating omics findings can lead to more precise and effective, sex-specific asthma management strategies.
- Clinical guidelines should consider incorporating sex-specific omics evidence for improved patient care.
Related Concept Videos
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
204
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
204
01:29Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
01:20Asthma: Pathogenesis and Management
298
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
298
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
01:24Asthma-III: Symptoms and Complications
2.4K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.4K