Related Experiment Video

Updated: May 21, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

12.9K

Highlights of recent research focused on the treatment of advanced prostate cancer

Theodore Gourdin1

  • 1Department of Medicine - Division of Hematology Oncology, Medical University of South Carolina, Charleston, South Carolina, USA.

Current Opinion in Oncology
|March 20, 2025
PubMed
Abstract

Insights

Recent research suggests earlier treatment with novel agents improves outcomes for advanced prostate cancer. Identifying optimal therapy sequences and patient selection for localized treatments are key areas of ongoing investigation.

Area of Science:

  • Oncology
  • Urology

Background:

  • Advanced prostate cancer management requires continuous innovation.
  • Optimizing treatment strategies is crucial for improving patient survival and quality of life.

Purpose of the Study:

  • To review recent research advancements in treating advanced prostate cancer.
  • To highlight novel therapeutic approaches and ongoing research directions.

Main Methods:

  • Review of recent randomized clinical trials.
  • Analysis of emerging treatment paradigms in advanced prostate cancer.

Main Results:

  • Early intervention with novel hormonal agents and chemotherapy shows promise.
  • Biomarker research is essential for selecting patients for targeted therapies.
  • Localized therapy may benefit select men with oligometastatic disease.
  • Radiopharmaceuticals are transforming treatment, with ongoing research into combinations and response biomarkers.

Conclusions:

  • Current research focuses on refining existing treatments and developing new therapeutic combinations.
  • Personalized medicine approaches, guided by biomarkers, are critical for advanced prostate cancer.
  • Continued investigation into novel agents and treatment sequencing is vital.
Keywords:
androgen deprivation therapybiomarkersnovel combinationsprostate cancerradiopharmaceuticals

More Related Videos

Focal Laser Ablation of Prostate Cancer: An Office Procedure11:07

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Published on: March 30, 2021

7.6K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.1K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
313
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.2K
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
315
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K