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Updated: May 21, 2025

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
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A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

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Determinants of Cardiac Myosin Binding Protein C in the General Population

Michael F Paus1,2, Magnus N Lyngbakken1,2, Arnljot Tveit2,3

  • 1Department of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway.

Clinical Chemistry
|March 20, 2025
PubMed

Insights

Cardiac myosin binding protein C (cMyC) is a novel biomarker. Elevated cMyC levels in the general population indicate cardiac remodeling, fibrosis, and dysfunction, independent of traditional risk factors.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Clinical Investigation

Background:

  • Cardiac myosin binding protein C (cMyC) is a novel, cardiac-specific biomarker.
  • Its role in chronic myocardial injury and left ventricular remodeling in the general population is not well understood.
  • The study aimed to investigate associations between cMyC and cardiovascular risk factors, chronic injury biomarkers, and cardiac imaging biomarkers.

Purpose of the Study:

  • To determine if cMyC concentrations correlate with cardiovascular risk factors.
  • To assess the relationship between cMyC and biomarkers of chronic myocardial injury.
  • To evaluate the association of cMyC with imaging biomarkers of cardiac anatomy, function, and fibrosis.

Main Methods:

  • Measured circulating cMyC, cardiac troponin I, and T in 3672 individuals from the general population.
  • Utilized echocardiography for all participants.
  • Conducted cardiovascular magnetic resonance (CMR) imaging in 199 participants to assess myocardial fibrosis.

Main Results:

  • Circulating cMyC was measurable in nearly all participants (99.6%).
  • cMyC showed positive associations with left ventricular mass and left atrial volume.
  • cMyC was inversely associated with renal function and left ventricular systolic/diastolic function, and positively associated with focal myocardial fibrosis.

Conclusions:

  • In the general population, cMyC concentrations are linked to cardiovascular risk factors.
  • Circulating cMyC reflects left ventricular remodeling, including focal myocardial fibrosis.
  • cMyC is associated with systolic and diastolic dysfunction, independent of traditional risk factors.
Abstract

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