Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

45
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
45
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

51
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
51
Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

55
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
55
Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

197
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
197
Renal Clearance01:23

Renal Clearance

585
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
585
Determination of Renal Drug Clearance: Graphical and Midpoint Methods01:07

Determination of Renal Drug Clearance: Graphical and Midpoint Methods

64
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
64

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors associated with the development of severe mitral regurgitation in patients with heart failure.

Open heart·2026
Same author

Utility of multiparametric MRI including T1/T2 mapping and IVIM/diffusion imaging for the evaluation of non-obstructive azoospermia.

Magma (New York, N.Y.)·2025
Same author

Gold nanoshells for prostate cancer treatment: evidence for deposition in abdominal organs.

Abdominal radiology (New York)·2024
Same author

Applying Natural Language Processing to Single-Report Prediction of Metastatic Disease Response Using the OR-RADS Lexicon.

Cancers·2023
Same author

Association of Patient and Imaging-Related Factors With False Negative MRI-Targeted Prostate Biopsies of Suspicious PI-RADS 4 and 5 Lesions.

Urology·2022
Same author

Spontaneous Regression and Complete Response to Immune Checkpoint Blockade in a Case of High-Grade Neuroendocrine Carcinoma.

JCO precision oncology·2022

Related Experiment Video

Updated: May 21, 2025

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens
06:02

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens

Published on: April 18, 2013

11.7K

Mean creatinine decrease after administration of intravenous contrast in patients with renal dysfunction:

Jeffrey H Newhouse1, Firas Ahmed2, James Ellis3

  • 1Department of Radiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.

Acta Radiologica (Stockholm, Sweden : 1987)
|March 20, 2025
PubMed
Summary

Traditional contrast nephropathy risk assessment is misleading. Analyzing mean serum creatinine changes reveals a slight, significant decrease after contrast, suggesting lower risks than previously estimated for contrast-induced acute kidney injury (AKI).

Keywords:
Contrast mediaacute kidney injurycontrast nephropathycontrast nephrotoxicitymean creatinine changes and contrast nephropathypost-contrast nephropathypost-contrast nephrotoxicity

More Related Videos

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
06:38

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Published on: March 11, 2016

12.0K
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.1K

Related Experiment Videos

Last Updated: May 21, 2025

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens
06:02

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens

Published on: April 18, 2013

11.7K
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
06:38

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Published on: March 11, 2016

12.0K
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.1K

Area of Science:

  • Nephrology
  • Radiology
  • Pharmacology

Background:

  • Contrast nephropathy risk is often assessed using threshold-based increases in serum creatinine (SCr), which can be misleading.
  • This traditional method overlooks creatinine decreases and continuous renal function data, potentially overestimating contrast-induced acute kidney injury (AKI) risk.
  • Analyzing mean SCr changes offers a more accurate assessment of contrast's impact on renal function.

Purpose of the Study:

  • To analyze published data for calculating mean SCr changes following intravenous contrast administration.
  • To evaluate the significance of these mean SCr changes in patients with pre-existing renal dysfunction.

Main Methods:

  • Systematic review of 14 publications involving 2057 patients with pre-existing renal dysfunction.
  • Inclusion criteria specified modern contrast agents, dose, and availability of SCr means and standard deviations pre- and post-contrast.
  • Analysis focused on mean SCr changes and their statistical significance at various post-contrast intervals.

Main Results:

  • Mean SCr decreased significantly from 148.6 µmol/L pre-contrast to 144.1 µmol/L post-contrast.
  • Significant SCr reductions were observed at 4, 7, and 10 days post-contrast, particularly in patients receiving hydration.
  • Only 6.6% of patients met traditional study-defined thresholds for contrast nephropathy.

Conclusions:

  • The observed slight, significant SCr improvement suggests that contrast-induced AKI risk estimates may have been erroneously high.
  • The risk of clinically significant AKI after contrast is unlikely in patients with moderate renal failure.
  • Mean post-contrast SCr decline should guide clinical decisions, and future studies should analyze mean changes, variation, and significance.