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Updated: May 21, 2025
Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli
Published on: March 24, 2023
Widespread antibiotic heterotolerance in bacteria remains undetected by resistance assays
Bram Van den Bergh1, Philip Ruelens1, Lieze Agten1
1Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems, KU Leuven, Belgium; Center for Microbiology, Vlaams Instituut voor Biotechnologie, VIB-KU Leuven, Belgium.
Abstract:
Despite global efforts, antimicrobial resistance persists. Mechanisms like heterotolerance further undermine antibiotic effectiveness. Testing > 1000 clinical strains revealed widespread heterotolerance largely missed by conventional MIC-based diagnostics. Since AMR alone does not predict treatment success, new tests and strategies incorporating tolerance data are urgently needed to significantly improve patient outcomes.
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