Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

378
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
378
Aging01:26

Aging

1.1K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Astrocyte-neurone crosstalk mediates dexmedetomidine sedation.

British journal of anaesthesia·2026
Same author

Enhancing support for family physician anesthetists in Canada.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same author

Self-Harm Presentations to a Pediatric Trauma Centre During the First Year of the COVID-19 Pandemic.

Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent·2026
Same author

A perfect storm: consequences of excess inhibitory neurotransmission after anaesthesia and surgery.

British journal of anaesthesia·2026
Same author

Targeting γ-aminobutyric acid type A receptors to mitigate perioperative neurocognitive disorders: a narrative review.

British journal of anaesthesia·2026
Same author

SmartTots and the Power of Scientific Public-Private Partnerships With the US Food and Drug Administration.

Anesthesia and analgesia·2025

Related Experiment Video

Updated: May 6, 2026

Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

14.8K

Revisiting anesthesia-induced preconditioning for neuroprotection in the aging brain: a narrative review.

Tao Zhang1,2,3, Woosuk Chung1,2,3, Beverley A Orser4,5,6

  • 1Department of Medical Science, Chungnam National University School of Medicine, Daejeon, Korea.

Korean Journal of Anesthesiology
|March 20, 2025
PubMed
Summary
This summary is machine-generated.

Anesthesia preconditioning shows promise for neuroprotection in older surgical patients, but clinical results lag. Physical prehabilitation may restore its effectiveness by improving mitochondrial function.

Keywords:
AgingAnesthesiaIschemic preconditioningMitochondriaPreconditioningPrehabilitationPreoperative exercise

More Related Videos

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
09:48

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

13.7K
Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
10:13

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

7.4K

Related Experiment Videos

Last Updated: May 6, 2026

Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

14.8K
Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
09:48

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

13.7K
Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
10:13

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

7.4K

Area of Science:

  • Geriatric Medicine
  • Neuroscience
  • Anesthesiology

Background:

  • Older adults undergoing surgery face risks of perioperative stroke.
  • Anesthesia preconditioning shows neuroprotective potential in preclinical models by preserving mitochondrial function and reducing inflammation.
  • Clinical translation of anesthetic preconditioning is limited in older populations due to age-related mitochondrial dysfunction and comorbidities.

Purpose of the Study:

  • To explore the potential of physical prehabilitation to restore the neuroprotective effects of anesthetic preconditioning in older surgical patients.
  • To investigate the role of mitochondrial function in mediating anesthetic preconditioning and its potential restoration through physical interventions.

Main Methods:

  • Review of preclinical studies on anesthesia-induced preconditioning and neuroprotection.
  • Analysis of factors contributing to the discordance between preclinical and clinical outcomes in older adults.
  • Examination of emerging evidence on physical prehabilitation and its impact on mitochondrial function.

Main Results:

  • Anesthetic preconditioning's neuroprotective effects are diminished in aging brains, potentially due to mitochondrial dysfunction.
  • Physical prehabilitation, a component of Enhanced Recovery After Surgery, may positively influence mitochondrial function.
  • Physical prehabilitation could potentially restore the efficacy of anesthetic preconditioning.

Conclusions:

  • Mitochondria are key targets for restoring anesthetic preconditioning's neuroprotective effects in the aging brain.
  • Physical prehabilitation may enhance neurological outcomes for older surgical patients by improving mitochondrial function and restoring anesthetic preconditioning.
  • Further research is warranted to confirm the impact of physical prehabilitation on mitochondrial function and anesthetic preconditioning in perioperative care.