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Modified Shi Hui San decoction ameliorates murine experimental colitis through multiple mechanisms.
Xinyi Wu1, Wenwen Yu2, Ruichang Luo1
1College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Fitoterapia
|March 20, 2025
Summary
Modified Shi Hui San decoction (MSHSD) effectively treats experimental colitis in mice by reducing inflammation and restoring gut microbiota balance. These findings support its clinical use for ulcerative colitis (UC).
Area of Science:
- Gastroenterology
- Pharmacology
- Microbiology
Background:
- Modified Shi Hui San (MSHS) shows clinical efficacy for ulcerative colitis (UC) in China.
- The precise mechanisms of MSHS action in UC require further elucidation.
Purpose of the Study:
- To investigate the therapeutic effects of modified Shi Hui San decoction (MSHSD) in a murine model of experimental colitis.
- To explore the underlying mechanisms of MSHSD's therapeutic action.
Main Methods:
- Murine model of colitis induced by 2.5% dextran sodium sulfate (DSS).
- Treatment with MSHSD at 6.25 or 25 g/kg for 10 days.
- Evaluation included clinical symptoms, histopathology, mucosal barrier integrity, biochemical assays, and gut microbiota analysis.
Main Results:
- MSHSD significantly ameliorated experimental colitis in DSS-treated mice.
- Treatment suppressed inflammation, restored intestinal mucus barrier, alleviated oxidative stress, and reestablished immunity.
- MSHSD normalized the gut microbiota structure from an imbalanced state.
Conclusions:
- This study elucidates the mechanisms by which MSHSD alleviates experimental colitis.
- Findings support the clinical application of MSHS for treating ulcerative colitis.
