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This summary is machine-generated.

Multiple primary malignancies (MPM) are linked to distinct gut microbiome profiles. This study identified specific bacteria and enteroviruses associated with MPM and colorectal cancer (CRC), offering insights into cancer development.

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Area of Science:

  • Microbiome research
  • Oncology
  • Genomics

Background:

  • Multiple primary malignancies (MPM) involve two or more independent primary tumors.
  • The interplay between the gut microbiome and various cancers is an emerging area of research.

Purpose of the Study:

  • To investigate the relationship between the gut microbiome and patients with multiple primary malignancies (MPMs).

Main Methods:

  • Metagenomic sequencing was performed on 27 MPM patients, 30 colorectal cancer (CRC) patients, and 30 healthy controls.
  • Knowledge graphs were constructed for gut bacteria and enteroviruses.
  • Wilcoxon rank-sum test identified characteristic gut microbiome features.

Main Results:

  • Significant differences in gut bacteria (e.g., Dialister, Fecalibacterium, Mediterraneibacter) were observed between MPM patients and healthy individuals.
  • Specific bacteria (e.g., Parvimonas, Dialister, Mediterraneibacter) were more abundant in MPM patients with co-occurring CRC compared to CRC patients alone.
  • Distinct enteroviruses (e.g., Triavirus, Punavirus, Lilyvirus) differed between MPM patients and healthy individuals, with lower abundance in MPM patients.

Conclusions:

  • A knowledge graph of the gut microbiome in MPM patients was successfully generated.
  • These findings provide foundational data for future research into the role of the gut microbiome in MPM.