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Spliceosome protein EFTUD2: A potential pathogenetic factor in tumorigenesis and some developmental defects (Review)

Ankang Yin1, Qiuyu Zhu1, Yi Chen2

  • 1School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China.

Molecular Medicine Reports
|March 21, 2025
PubMed
Summary

Elongation factor Tu GTP binding domain containing 2 (EFTUD2) is crucial for mRNA splicing and regulates development and immunity. Mutations in EFTUD2 cause developmental defects and diseases, while its overexpression promotes cancer progression.

Keywords:
RNA splicingdevelopmental defectelongation factor tu guanosine‑5'‑triphosphate binding domain containing 2gene mutationtumorigenesis

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